Co-expression of the aryl hydrocarbon receptor and estrogen receptor in the developing teeth of rat offspring after rat mothers' exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and the protective action of α-tocopherol and acetylsalicylic acid.
Identifieur interne : 000583 ( Main/Exploration ); précédent : 000582; suivant : 000584Co-expression of the aryl hydrocarbon receptor and estrogen receptor in the developing teeth of rat offspring after rat mothers' exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and the protective action of α-tocopherol and acetylsalicylic acid.
Auteurs : Maciej Dobrzy Ski [Pologne] ; Piotr Kuropka [Pologne] ; Anna Le K W [Pologne] ; Katarzyna Herman [Pologne] ; Małgorzata Tarnowska [Pologne] ; Rafał J. Wiglusz [Pologne]Source :
- Advances in clinical and experimental medicine : official organ Wroclaw Medical University [ 1899-5276 ] ; 2019.
Descripteurs français
- KwdFr :
- Acide acétylsalicylique (pharmacologie), Animaux (MeSH), Anti-inflammatoires non stéroïdiens (pharmacologie), Antioxydants (pharmacologie), Dent (croissance et développement), Dibenzodioxines polychlorées (toxicité), Femelle (MeSH), Humains (MeSH), Immunohistochimie (MeSH), Malformations dentaires (induit chimiquement), Mères (MeSH), Polluants environnementaux (MeSH), Rats (MeSH), Récepteurs des oestrogènes (métabolisme), Récepteurs à hydrocarbure aromatique (métabolisme), Tocophérols (pharmacologie), alpha-Tocophérol (pharmacologie).
- MESH :
- croissance et développement : Dent.
- induit chimiquement : Malformations dentaires.
- métabolisme : Récepteurs des oestrogènes, Récepteurs à hydrocarbure aromatique.
- pharmacologie : Acide acétylsalicylique, Anti-inflammatoires non stéroïdiens, Antioxydants, Tocophérols, alpha-Tocophérol.
- toxicité : Dibenzodioxines polychlorées.
- Animaux, Femelle, Humains, Immunohistochimie, Mères, Polluants environnementaux, Rats.
English descriptors
- KwdEn :
- Animals (MeSH), Anti-Inflammatory Agents, Non-Steroidal (pharmacology), Antioxidants (pharmacology), Aspirin (pharmacology), Environmental Pollutants (MeSH), Female (MeSH), Humans (MeSH), Immunohistochemistry (MeSH), Mothers (MeSH), Polychlorinated Dibenzodioxins (toxicity), Rats (MeSH), Receptors, Aryl Hydrocarbon (metabolism), Receptors, Estrogen (metabolism), Tocopherols (pharmacology), Tooth (growth & development), Tooth Abnormalities (chemically induced), alpha-Tocopherol (pharmacology).
- MESH :
- chemical , metabolism : Receptors, Aryl Hydrocarbon, Receptors, Estrogen.
- chemical , pharmacology : Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Aspirin, Tocopherols, alpha-Tocopherol.
- chemical , toxicity : Polychlorinated Dibenzodioxins.
- chemically induced : Tooth Abnormalities.
- growth & development : Tooth.
- Animals, Environmental Pollutants, Female, Humans, Immunohistochemistry, Mothers, Rats.
Abstract
BACKGROUND
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can cause adverse effects in many organs. Toxic effects are caused due to the formation of a TCDD complex with the cytoplasmatic aryl hydrocarbon receptor (AhR), whose mechanism of action is similar to that of the estrogen receptor (ER). Some substances, including α-tocopherol (E) and acetylsalicylic acid (ASA), can reduce the toxic effects of TCDD in offspring.
OBJECTIVES
The objective of this study was to evaluate the co-expression of AhR and ER in the incisors of rat offspring whose mothers were exposed to TCDD, using immunohistochemical and histological techniques. Moreover, the possible protective role of E and ASA was investigated.
MATERIAL AND METHODS
Four groups of 2-day-old rat offspring, whose mothers were intoxicated by TCDD before mating, were established: control group (C), TCDD group, TCDD+E group and TCDD+ASA group.
RESULTS
In the TCDD group, there was an increase in ER expression and a decrease in AhR expression in comparison with the C group. In the TCDD+E and TCDD+ASA groups, there was a weak or negative ER expression and slightly stronger expression of AhR than in the TCDD group.
CONCLUSIONS
The co-expression of AhR and ER during tooth development suggests the role of AhR and ER in the control of this process. Both receptors are also involved in the process of detoxification of TCDD. The increase in AhR in TCDD+E and TCDD+ASA groups indicate a preventive action of antioxidant and antiinflammatory pharmaceutics, which may limit negative effects of TCDD.
DOI: 10.17219/acem/99613
PubMed: 30684314
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Co-expression of the aryl hydrocarbon receptor and estrogen receptor in the developing teeth of rat offspring after rat mothers' exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and the protective action of α-tocopherol and acetylsalicylic acid.</title><author><name sortKey="Dobrzy Ski, Maciej" sort="Dobrzy Ski, Maciej" uniqKey="Dobrzy Ski M" first="Maciej" last="Dobrzy Ski">Maciej Dobrzy Ski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University</wicri:regionArea><wicri:noRegion>Wroclaw Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Kuropka, Piotr" sort="Kuropka, Piotr" uniqKey="Kuropka P" first="Piotr" last="Kuropka">Piotr Kuropka</name><affiliation wicri:level="1"><nlm:affiliation>Department Histology and Embriology, Wroclaw University of Environmental and Life Sciences, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department Histology and Embriology, Wroclaw University of Environmental and Life Sciences</wicri:regionArea><wicri:noRegion>Wroclaw University of Environmental and Life Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Le K W, Anna" sort="Le K W, Anna" uniqKey="Le K W A" first="Anna" last="Le K W">Anna Le K W</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nervous System Diseases, Wroclaw Medical University, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Nervous System Diseases, Wroclaw Medical University</wicri:regionArea><wicri:noRegion>Wroclaw Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Herman, Katarzyna" sort="Herman, Katarzyna" uniqKey="Herman K" first="Katarzyna" last="Herman">Katarzyna Herman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University</wicri:regionArea><wicri:noRegion>Wroclaw Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Tarnowska, Malgorzata" sort="Tarnowska, Malgorzata" uniqKey="Tarnowska M" first="Małgorzata" last="Tarnowska">Małgorzata Tarnowska</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nervous System Diseases, Wroclaw Medical University, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Nervous System Diseases, Wroclaw Medical University</wicri:regionArea><wicri:noRegion>Wroclaw Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Wiglusz, Rafal J" sort="Wiglusz, Rafal J" uniqKey="Wiglusz R" first="Rafał J" last="Wiglusz">Rafał J. Wiglusz</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Wrocław, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Wrocław</wicri:regionArea><wicri:noRegion>Wrocław</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Physico-Chemistry of Microorganisms, Institute of Genetics and Microbiology, University of Wrocław, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Physico-Chemistry of Microorganisms, Institute of Genetics and Microbiology, University of Wrocław</wicri:regionArea><wicri:noRegion>University of Wrocław</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30684314</idno><idno type="pmid">30684314</idno><idno type="doi">10.17219/acem/99613</idno><idno type="wicri:Area/Main/Corpus">000577</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000577</idno><idno type="wicri:Area/Main/Curation">000577</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000577</idno><idno type="wicri:Area/Main/Exploration">000577</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Co-expression of the aryl hydrocarbon receptor and estrogen receptor in the developing teeth of rat offspring after rat mothers' exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and the protective action of α-tocopherol and acetylsalicylic acid.</title><author><name sortKey="Dobrzy Ski, Maciej" sort="Dobrzy Ski, Maciej" uniqKey="Dobrzy Ski M" first="Maciej" last="Dobrzy Ski">Maciej Dobrzy Ski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University</wicri:regionArea><wicri:noRegion>Wroclaw Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Kuropka, Piotr" sort="Kuropka, Piotr" uniqKey="Kuropka P" first="Piotr" last="Kuropka">Piotr Kuropka</name><affiliation wicri:level="1"><nlm:affiliation>Department Histology and Embriology, Wroclaw University of Environmental and Life Sciences, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department Histology and Embriology, Wroclaw University of Environmental and Life Sciences</wicri:regionArea><wicri:noRegion>Wroclaw University of Environmental and Life Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Le K W, Anna" sort="Le K W, Anna" uniqKey="Le K W A" first="Anna" last="Le K W">Anna Le K W</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nervous System Diseases, Wroclaw Medical University, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Nervous System Diseases, Wroclaw Medical University</wicri:regionArea><wicri:noRegion>Wroclaw Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Herman, Katarzyna" sort="Herman, Katarzyna" uniqKey="Herman K" first="Katarzyna" last="Herman">Katarzyna Herman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University</wicri:regionArea><wicri:noRegion>Wroclaw Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Tarnowska, Malgorzata" sort="Tarnowska, Malgorzata" uniqKey="Tarnowska M" first="Małgorzata" last="Tarnowska">Małgorzata Tarnowska</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nervous System Diseases, Wroclaw Medical University, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Nervous System Diseases, Wroclaw Medical University</wicri:regionArea><wicri:noRegion>Wroclaw Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Wiglusz, Rafal J" sort="Wiglusz, Rafal J" uniqKey="Wiglusz R" first="Rafał J" last="Wiglusz">Rafał J. Wiglusz</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Wrocław, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Wrocław</wicri:regionArea><wicri:noRegion>Wrocław</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Physico-Chemistry of Microorganisms, Institute of Genetics and Microbiology, University of Wrocław, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Physico-Chemistry of Microorganisms, Institute of Genetics and Microbiology, University of Wrocław</wicri:regionArea><wicri:noRegion>University of Wrocław</wicri:noRegion></affiliation></author></analytic><series><title level="j">Advances in clinical and experimental medicine : official organ Wroclaw Medical University</title><idno type="ISSN">1899-5276</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Anti-Inflammatory Agents, Non-Steroidal (pharmacology)</term><term>Antioxidants (pharmacology)</term><term>Aspirin (pharmacology)</term><term>Environmental Pollutants (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Immunohistochemistry (MeSH)</term><term>Mothers (MeSH)</term><term>Polychlorinated Dibenzodioxins (toxicity)</term><term>Rats (MeSH)</term><term>Receptors, Aryl Hydrocarbon (metabolism)</term><term>Receptors, Estrogen (metabolism)</term><term>Tocopherols (pharmacology)</term><term>Tooth (growth & development)</term><term>Tooth Abnormalities (chemically induced)</term><term>alpha-Tocopherol (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide acétylsalicylique (pharmacologie)</term><term>Animaux (MeSH)</term><term>Anti-inflammatoires non stéroïdiens (pharmacologie)</term><term>Antioxydants (pharmacologie)</term><term>Dent (croissance et développement)</term><term>Dibenzodioxines polychlorées (toxicité)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Immunohistochimie (MeSH)</term><term>Malformations dentaires (induit chimiquement)</term><term>Mères (MeSH)</term><term>Polluants environnementaux (MeSH)</term><term>Rats (MeSH)</term><term>Récepteurs des oestrogènes (métabolisme)</term><term>Récepteurs à hydrocarbure aromatique (métabolisme)</term><term>Tocophérols (pharmacologie)</term><term>alpha-Tocophérol (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Aryl Hydrocarbon</term><term>Receptors, Estrogen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term><term>Antioxidants</term><term>Aspirin</term><term>Tocopherols</term><term>alpha-Tocopherol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Polychlorinated Dibenzodioxins</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Tooth Abnormalities</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Dent</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Tooth</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Malformations dentaires</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Récepteurs des oestrogènes</term><term>Récepteurs à hydrocarbure aromatique</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acide acétylsalicylique</term><term>Anti-inflammatoires non stéroïdiens</term><term>Antioxydants</term><term>Tocophérols</term><term>alpha-Tocophérol</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Dibenzodioxines polychlorées</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Environmental Pollutants</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Mothers</term><term>Rats</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Immunohistochimie</term><term>Mères</term><term>Polluants environnementaux</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can cause adverse effects in many organs. Toxic effects are caused due to the formation of a TCDD complex with the cytoplasmatic aryl hydrocarbon receptor (AhR), whose mechanism of action is similar to that of the estrogen receptor (ER). Some substances, including α-tocopherol (E) and acetylsalicylic acid (ASA), can reduce the toxic effects of TCDD in offspring.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>The objective of this study was to evaluate the co-expression of AhR and ER in the incisors of rat offspring whose mothers were exposed to TCDD, using immunohistochemical and histological techniques. Moreover, the possible protective role of E and ASA was investigated.</p></div><div type="abstract" xml:lang="en"><p><b>MATERIAL AND METHODS</b></p><p>Four groups of 2-day-old rat offspring, whose mothers were intoxicated by TCDD before mating, were established: control group (C), TCDD group, TCDD+E group and TCDD+ASA group.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In the TCDD group, there was an increase in ER expression and a decrease in AhR expression in comparison with the C group. In the TCDD+E and TCDD+ASA groups, there was a weak or negative ER expression and slightly stronger expression of AhR than in the TCDD group.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>The co-expression of AhR and ER during tooth development suggests the role of AhR and ER in the control of this process. Both receptors are also involved in the process of detoxification of TCDD. The increase in AhR in TCDD+E and TCDD+ASA groups indicate a preventive action of antioxidant and antiinflammatory pharmaceutics, which may limit negative effects of TCDD.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">30684314</PMID><DateCompleted><Year>2019</Year><Month>08</Month><Day>30</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1899-5276</ISSN><JournalIssue CitedMedium="Print"><Volume>28</Volume><Issue>7</Issue><PubDate><Year>2019</Year><Month>07</Month></PubDate></JournalIssue><Title>Advances in clinical and experimental medicine : official organ Wroclaw Medical University</Title><ISOAbbreviation>Adv Clin Exp Med</ISOAbbreviation></Journal><ArticleTitle>Co-expression of the aryl hydrocarbon receptor and estrogen receptor in the developing teeth of rat offspring after rat mothers' exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and the protective action of α-tocopherol and acetylsalicylic acid.</ArticleTitle><Pagination><MedlinePgn>973-980</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.17219/acem/99613</ELocationID><Abstract><AbstractText Label="BACKGROUND">Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can cause adverse effects in many organs. Toxic effects are caused due to the formation of a TCDD complex with the cytoplasmatic aryl hydrocarbon receptor (AhR), whose mechanism of action is similar to that of the estrogen receptor (ER). Some substances, including α-tocopherol (E) and acetylsalicylic acid (ASA), can reduce the toxic effects of TCDD in offspring.</AbstractText><AbstractText Label="OBJECTIVES">The objective of this study was to evaluate the co-expression of AhR and ER in the incisors of rat offspring whose mothers were exposed to TCDD, using immunohistochemical and histological techniques. Moreover, the possible protective role of E and ASA was investigated.</AbstractText><AbstractText Label="MATERIAL AND METHODS">Four groups of 2-day-old rat offspring, whose mothers were intoxicated by TCDD before mating, were established: control group (C), TCDD group, TCDD+E group and TCDD+ASA group.</AbstractText><AbstractText Label="RESULTS">In the TCDD group, there was an increase in ER expression and a decrease in AhR expression in comparison with the C group. In the TCDD+E and TCDD+ASA groups, there was a weak or negative ER expression and slightly stronger expression of AhR than in the TCDD group.</AbstractText><AbstractText Label="CONCLUSIONS">The co-expression of AhR and ER during tooth development suggests the role of AhR and ER in the control of this process. Both receptors are also involved in the process of detoxification of TCDD. The increase in AhR in TCDD+E and TCDD+ASA groups indicate a preventive action of antioxidant and antiinflammatory pharmaceutics, which may limit negative effects of TCDD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dobrzyński</LastName><ForeName>Maciej</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuropka</LastName><ForeName>Piotr</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department Histology and Embriology, Wroclaw University of Environmental and Life Sciences, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leśków</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Nervous System Diseases, Wroclaw Medical University, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herman</LastName><ForeName>Katarzyna</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tarnowska</LastName><ForeName>Małgorzata</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Nervous System Diseases, Wroclaw Medical University, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wiglusz</LastName><ForeName>Rafał J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Wrocław, Poland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Physico-Chemistry of Microorganisms, Institute of Genetics and Microbiology, University of Wrocław, Poland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D023362">Evaluation Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Poland</Country><MedlineTA>Adv Clin Exp Med</MedlineTA><NlmUniqueID>101138582</NlmUniqueID><ISSNLinking>1899-5276</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000894">Anti-Inflammatory Agents, Non-Steroidal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004785">Environmental Pollutants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000072317">Polychlorinated Dibenzodioxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018336">Receptors, Aryl Hydrocarbon</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011960">Receptors, Estrogen</NameOfSubstance></Chemical><Chemical><RegistryNumber>H4N855PNZ1</RegistryNumber><NameOfSubstance UI="D024502">alpha-Tocopherol</NameOfSubstance></Chemical><Chemical><RegistryNumber>R0ZB2556P8</RegistryNumber><NameOfSubstance UI="D024505">Tocopherols</NameOfSubstance></Chemical><Chemical><RegistryNumber>R16CO5Y76E</RegistryNumber><NameOfSubstance UI="D001241">Aspirin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000894" MajorTopicYN="N">Anti-Inflammatory Agents, Non-Steroidal</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001241" MajorTopicYN="N">Aspirin</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004785" MajorTopicYN="N">Environmental Pollutants</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009035" MajorTopicYN="N">Mothers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000072317" MajorTopicYN="N">Polychlorinated Dibenzodioxins</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018336" MajorTopicYN="N">Receptors, Aryl Hydrocarbon</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011960" MajorTopicYN="N">Receptors, Estrogen</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024505" MajorTopicYN="N">Tocopherols</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014070" MajorTopicYN="N">Tooth</DescriptorName><QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014071" MajorTopicYN="N">Tooth Abnormalities</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024502" MajorTopicYN="N">alpha-Tocopherol</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">aryl hydrocarbon receptor</Keyword><Keyword MajorTopicYN="Y">dioxin</Keyword><Keyword MajorTopicYN="Y">estrogen receptor</Keyword><Keyword MajorTopicYN="Y">rat</Keyword><Keyword MajorTopicYN="Y">tooth</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>1</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>8</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>1</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30684314</ArticleId><ArticleId IdType="doi">10.17219/acem/99613</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pologne</li></country></list><tree><country name="Pologne"><noRegion><name sortKey="Dobrzy Ski, Maciej" sort="Dobrzy Ski, Maciej" uniqKey="Dobrzy Ski M" first="Maciej" last="Dobrzy Ski">Maciej Dobrzy Ski</name></noRegion><name sortKey="Herman, Katarzyna" sort="Herman, Katarzyna" uniqKey="Herman K" first="Katarzyna" last="Herman">Katarzyna Herman</name><name sortKey="Kuropka, Piotr" sort="Kuropka, Piotr" uniqKey="Kuropka P" first="Piotr" last="Kuropka">Piotr Kuropka</name><name sortKey="Le K W, Anna" sort="Le K W, Anna" uniqKey="Le K W A" first="Anna" last="Le K W">Anna Le K W</name><name sortKey="Tarnowska, Malgorzata" sort="Tarnowska, Malgorzata" uniqKey="Tarnowska M" first="Małgorzata" last="Tarnowska">Małgorzata Tarnowska</name><name sortKey="Wiglusz, Rafal J" sort="Wiglusz, Rafal J" uniqKey="Wiglusz R" first="Rafał J" last="Wiglusz">Rafał J. Wiglusz</name><name sortKey="Wiglusz, Rafal J" sort="Wiglusz, Rafal J" uniqKey="Wiglusz R" first="Rafał J" last="Wiglusz">Rafał J. Wiglusz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Co-expression of the aryl hydrocarbon receptor and estrogen receptor in the developing teeth of rat offspring after rat mothers' exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and the protective action of α-tocopherol and acetylsalicylic acid.
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